J M Chen Selected Research

Hereditary pancreatitis

1/2008	Copy number variations in chronic pancreatitis.
2/2004	Two novel severe mutations in the pancreatic secretory trypsin inhibitor gene (SPINK1) cause familial and/or hereditary pancreatitis.
9/2001	Molecular pathology and evolutionary and physiological implications of pancreatitis-associated cationic trypsinogen mutations.
3/2001	Mutational screening of the cationic trypsinogen gene in a large cohort of subjects with idiopathic chronic pancreatitis.
7/2000	Genes, cloned cDNAs, and proteins of human trypsinogens and pancreatitis-associated cationic trypsinogen mutations.
1/2000	Origin and implication of the hereditary pancreatitis-associated N21I mutation in the cationic trypsinogen gene.

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J M Chen Research Topics

Disease

8	Neoplasms (Cancer) 05/2022 - 05/2000
8	Pancreatitis 01/2008 - 07/2000
6	Hereditary pancreatitis 01/2008 - 01/2000
5	Chronic Pancreatitis 01/2008 - 01/2000
3	Infections 02/2022 - 11/2000
3	Experimental Arthritis 03/2006 - 08/2003
3	Autolysis 09/2001 - 07/2000
2	Pancreatic Fistula (Pancreatic Fistulas) 02/2022 - 01/2018
2	Liver Diseases (Liver Disease) 07/2020 - 04/2015
2	Adenocarcinoma 07/2020 - 05/2019
2	Liver Cirrhosis (Hepatic Cirrhosis) 08/2017 - 06/2017
2	Heart Failure 04/2009 - 08/2001
2	Meniere Disease (Menieres Disease) 08/2000 - 07/2000
1	Head and Neck Neoplasms (Head and Neck Cancer) 02/2022
1	Bile Duct Neoplasms (Bile Duct Cancer) 02/2022
1	Infarction (Infarctions) 01/2022
1	Neuroinflammatory Diseases 01/2022
1	Cerebral Infarction 01/2022
1	Low Cardiac Output 11/2021
1	Muscular Diseases (Myopathy) 01/2021
1	Amyloidosis 01/2021
1	Myopia 12/2020
1	Stroke (Strokes) 12/2019
1	Tricuspid Valve Insufficiency (Insufficiency, Tricuspid Valve) 12/2019
1	Benign Paroxysmal Positional Vertigo 11/2019
1	Dizziness (Lightheadedness) 11/2019
1	Anemia 07/2019
1	Hypertension (High Blood Pressure) 07/2019
1	Chronic Renal Insufficiency 07/2019
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 07/2019
1	Peripheral Arterial Disease 07/2019
1	Inflammation (Inflammations) 05/2019
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 05/2019
1	Arteriovenous Fistula 02/2018
1	Hemorrhage 02/2018
1	Hydronephrosis 02/2018
1	Pneumothorax 02/2018
1	Fever (Fevers) 02/2018
1	Kidney Calculi (Kidney Stone) 02/2018
1	Blindness (Hysterical Blindness) 02/2018
1	Orbital Fractures (Fracture, Orbital) 08/2017
1	Exophthalmos (Proptosis) 08/2017
1	Abscess 09/2016
1	Dyspnea (Shortness of Breath) 09/2016
1	Hearing Loss (Hearing Impairment) 08/2016
1	Chronic Hepatitis B 07/2016
1	Tetraploidy 02/2016
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2016
1	Lung Neoplasms (Lung Cancer) 01/2016
1	Teratoma (Teratoid Tumor) 01/2016
1	Reperfusion Injury 09/2015
1	Spinal Cord Ischemia 09/2015

Drug/Important Bio-Agent (IBA)

11	TrypsinogenIBA 01/2008 - 01/2000
4	Proteins (Proteins, Gene)FDA Link 07/2019 - 07/2000
4	DNA (Deoxyribonucleic Acid)IBA 07/2016 - 07/2000
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2015 - 08/2003
4	Kazal Pancreatic Trypsin InhibitorIBA 01/2008 - 01/2000
3	Hemoglobins (Hemoglobin)IBA 07/2019 - 02/2018
3	ADAM17 ProteinIBA 03/2006 - 08/2003
2	CopperIBA 07/2020 - 01/2006
2	CreatinineIBA 07/2019 - 02/2018
2	Biomarkers (Surrogate Marker)IBA 07/2016 - 01/2016
2	EnzymesIBA 04/2015 - 01/2006
2	NucleotidesIBA 01/2008 - 02/2004
2	Peptides (Polypeptides)IBA 09/2001 - 07/2000
2	TrypsinIBA 09/2001 - 01/2001
2	Gentamicins (Gentamicin)FDA LinkGeneric 08/2000 - 07/2000
1	RNA (Ribonucleic Acid)IBA 01/2022
1	MetalsIBA 01/2022
1	Amyloid (Amyloid Fibrils)IBA 01/2021
1	Cytidine Diphosphate (CDP)IBA 07/2020
1	Therapeutic UsesIBA 11/2019
1	Uric Acid (Urate)IBA 07/2019
1	DiureticsIBA 07/2019
1	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 06/2017
1	Type II DNA Topoisomerases (Topoisomerase II)IBA 11/2016
1	Hepatitis B Surface Antigens (HBsAg)FDA Link 07/2016
1	Hepatitis B e AntigensIBA 07/2016
1	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 01/2016
1	Tumor Biomarkers (Tumor Markers)IBA 01/2016
1	Proto-Oncogene Proteins c-bcl-2 (Proto Oncogene Proteins c bcl 2)IBA 09/2015

Therapy/Procedure

4	Therapeutics 12/2019 - 07/2000
4	Heart Transplantation (Grafting, Heart) 02/2014 - 08/2001
2	Pancreatectomy 05/2022 - 07/2020
2	Pancreaticoduodenectomy 02/2022 - 01/2018
2	Punctures 02/2018 - 09/2016
2	Ligation 08/2017 - 06/2017
2	Cochlear Implantation 08/2016 - 10/2005
2	Heart-Assist Devices 11/2000 - 09/2000
1	Operative Time 02/2022
1	Mechanical Ventilators (Ventilator) 11/2021
1	Length of Stay 07/2021
1	Lenses 12/2020
1	Renal Replacement Therapy (Therapies, Renal Replacement) 12/2019
1	Exercise Therapy (Therapy, Exercise) 11/2019
1	Lithotripsy (Extracorporeal Shockwave Lithotripsy) 02/2018
1	Solid-State Lasers 02/2018
1	Telescopes 08/2017
1	Intraperitoneal Injections 06/2017
1	Tracheostomy 09/2016